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KMID : 0380620160480010072
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Korean Journal of Food Science and Technology
2016 Volume.48 No. 1 p.72 ~ p.76
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The Anti-melanogenic Effect of Geranium krameri Extract
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Kim Hyun-Soo
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Abstract
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We investigated the application of functional materials by examining a variety of physiological activities of Geranium krameri extract obtained from the National Institute of Horticultural and Herbal Science. Geranium krameri extract had a low cytotoxicity against murine melanoma B16F10 cells. At concentrations with little or no cytotoxicity, Geranium krameri extract showed high DPPH radical scavenging activity (ID50, 8.72 μg/mL) and anti-microbial activities against Bacillus subtilis, Escherichia coli, and Candida albicans. Additionally, Geranium krameri extract inhibited tyrosinase activity (ID50, 456.86 μg/mL) and decreased melanin content (ID50, 50.35 μg/mL). The treatment of B16F10 cells with Geranium krameri extract suppressed the protein expression of tyrosinase in a dose-dependent manner. These findings suggest that Geranium krameri extract inhibits melanin synthesis in murine melanoma B16F10 cells by suppressing intracellular tyrosinase expression, as well as directly inhibits tyrosinase activity simultaneously.
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KEYWORD
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Geranium krameri, melanin, tyrosinase
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